Facundo Batista, PhD

Associate Director / Ragon Institute of MGH, MIT and Harvard

Ragon Institute of MGH, MIT and Harvard 400 Technology Square Cambrige, MA 02139

Dr. Batista is a world leader in the study of B-cell immunology and antibody responses.


Since joining the Ragon Institute in 2016, Batista’s focus has turned further toward applied immunology, and his recent work involves the role of B-cell metabolism, including autophagy and mitochondrial metabolic reprogramming, in driving B-cell response. He is the recipient of the Royal Society Wolfson Research Merit Award, a fellow of the UK Academy of Medical Sciences and a fellow of the American Academy of Microbiology.

Training and Education

  • 2001
    Postdoctoral, Immunology, Cambridge University (MRC Molecular Biology Laboratory)
  • 1995
    PhD, Biology, International School of Advanced Studies (International Centre for Genetic Engineering and Biotechnology)
  • 1993
    MSc, Biology, International School of Advanced Studies
  • 1991
    BSc, Biology, University of Buenos Aires

Research Interests

Dr. Batista’s lab is interested in both the cellular and the molecular events that lead to the activation of B cells. They want to understand how these events affect the ability of B cells to produce antibodies. To do this, they work both in vivo and in vitro by combining state-of-the-art imaging technology with biochemistry and genetic models. For example, following B cells in vivo leads to a better understanding of where and when they are activated (Carrasco & Batista 2007; Gaya et al. 2015).

Also, by tracking single B cell receptor (BCR) molecules, they have shown how the cortical cytoskeleton network regulates receptor signalling (Mattila et al. 2013; Treanor et al. 2011; Treanor et al. 2010). Similarly, by studying actin regulators such as Cdc42 or Nck, the lab has shown that they play a major role in B cell activation and antibody production (Burbage et al. 2014; Castello et al. 2013).

The members of Dr. Batista’s lab have therefore been working and will continue to work toward a clearer understanding of B cell activation and antibody production at a cellular and molecular level with their innovative approach – this knowledge will aid everyone in the fight against infectious diseases and cancer.