Amping up HIV antibodies
August 26, 2021
Volume and Number
Vol. 372 Issue 6549 Starting Page: 1397
Burton, Dennis R.
The recent results (1) from the Antibody Mediated Prevention (AMP) study are a landmark in AIDS research. They show that a broadly neutralizing antibody (bnAb) can protect humans against infection with sensitive strains of HIV. BnAbs, antibodies that can neutralize a large fraction of globally circulating HIV strains, are the focus of many HIV vaccine efforts and of strategies to prevent or treat HIV by passive immunization (infusion with antibodies). This focus results from the enormous strain variability of HIV—only bnAbs can hope to counter this variability. The results have profound implications for HIV vaccine design and for the use of passively administered bnAbs. Within the context of earlier animal model studies, the AMP study results provide insight into the factors that are important for antibody protection against HIV.
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